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當前位置(zhì):首(shǒu)頁資料下載上海(hǎi)騰拔質(zhì)構(gòu)儀(yí)用於(yú)測定靜(jìng)電(diàn)紡絲納(nà)米纖(xiān)維的拉伸強度(dù)和(hé)斷裂(liè)伸長(cháng)率(shuài)

上(shàng)海騰(téng)拔質構儀用(yòng)於測定靜電(diàn)紡絲(sī)納(nà)米纖維(wéi)的拉(lā)伸強(qiáng)度和斷裂伸(shēn)長(cháng)率

發布時(shí)間(jiān):2023/3/17點擊(jī)次數(shù):2304

In this study, a novel nanofiber material with Polylactic acid (PLA), natural plant polysaccharides-Bletilla striata polysaccharide (BSP) and Rosmarinic acid (RA) as the raw materials to facilitate wound healing was well prepared through coaxial electrospinning. The morphology of RA-BSP-PVA@PLA nanofibers was characterized through scanning electron microscopy (SEM), and the successful formation of core-shell structure was verified under confocal laser microscopy (CLSM) and Fourier transform infrared spectroscopy (FTIR). RA-BSP-PVA@PLA exhibited suitable air permeability for wound healing, as indicated by the result of the water vapor permeability (WVTR) study. The results of tension test results indicated the RA-BSP-PVA@PLA nanofiber exhibited excellent flexibility and better accommodates wounds. Moreover, the biocompatibility of RA-BSP-PVA@PLA was examined through MTT assay. Lastly, RA-BSP-PVA@PLA nanofibers can induce wound tissue growth, as verified by the rat dorsal skin wound models and tissue sections. Furthermore, RA-BSP-PVA@PLA can facilitate the proliferation and transformation of early wound macrophages, and down-regulate MPO+ expression of on the wound, thus facilitating wound healing, as confirmed by the result of immunohistochemical. Thus, RA-BSPPVA@PLA nanofibers show great potential as wound dressings in wound healing.


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