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熱(rè)門搜(sōu)索:
Universal TA質構(gòu)儀
Rapid TA質(zhì)構(gòu)儀
魚(yú)糜彈性儀
質構儀探頭
凝膠(jiāo)強(qiáng)度(dù)測(cè)定儀
Rapid TA+質構(gòu)儀
肌(jī)肉嫩(nèn)度(dù)儀
iDeal TA物(wù)性測試(shì)儀(yí)
化(huà)工物(wù)性(xìng)分(fēn)析儀(yí)
TBUTA-23質構(gòu)儀
RTA-SCP土壤微型貫入(rù)儀(yí)
納米(mǐ)粒(lì)子高效自動(dòng)收集裝置
通(tōng)針性(xìng)測試儀(yí)
RTA-SA土壤(rǎng)粘附力(lì)測定(dìng)儀(yí)
茶樹新梢嫩(nèn)度測定(dìng)儀(yí)
微(wēi)針強度測(cè)定(dìng)儀
發布時(shí)間(jiān):2023/3/17
點擊(jī)次數(shù):2304
In this study, a novel nanofiber material with Polylactic acid (PLA), natural plant polysaccharides-Bletilla striata polysaccharide (BSP) and Rosmarinic acid (RA) as the raw materials to facilitate wound healing was well prepared through coaxial electrospinning. The morphology of RA-BSP-PVA@PLA nanofibers was characterized through scanning electron microscopy (SEM), and the successful formation of core-shell structure was verified under confocal laser microscopy (CLSM) and Fourier transform infrared spectroscopy (FTIR). RA-BSP-PVA@PLA exhibited suitable air permeability for wound healing, as indicated by the result of the water vapor permeability (WVTR) study. The results of tension test results indicated the RA-BSP-PVA@PLA nanofiber exhibited excellent flexibility and better accommodates wounds. Moreover, the biocompatibility of RA-BSP-PVA@PLA was examined through MTT assay. Lastly, RA-BSP-PVA@PLA nanofibers can induce wound tissue growth, as verified by the rat dorsal skin wound models and tissue sections. Furthermore, RA-BSP-PVA@PLA can facilitate the proliferation and transformation of early wound macrophages, and down-regulate MPO+ expression of on the wound, thus facilitating wound healing, as confirmed by the result of immunohistochemical. Thus, RA-BSPPVA@PLA nanofibers show great potential as wound dressings in wound healing.